反应 #689528

反应方程式

caesium carbonate

ethyl {4-[2-(2-chloroethoxy)acetylamino]phenyl}acetate

→

ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate

溶剂

acetonitrile

反应条件

后处理

1. 1
   过滤The reaction mixture is filtered
2. 2
   其他the filtrate is evaporated

实验过程

43.4 g (133 mmol) of caesium carbonate are added to a solution of 26.6 g (88.8 mmol) of ethyl {4-[2-(2-chloroethoxy)acetylamino]phenyl}acetate in 100 ml of acetonitrile, and the mixture is stirred at room temperature for 18 hours. The reaction mixture is filtered, and the filtrate is evaporated, giving ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate as a yellowish oil; ESI 264.

来源