反应 #68834

反应方程式

4-hydroxyphenylacetone

ammonia

hydrogen

→

1-(4-Hydroxyphenyl)propane-2-amine

溶剂

MeOH

反应条件

后处理

1. 1
   其他After complete reaction
2. 2
   过滤the mixture is filtrated
3. 3
   其他the solvent is removed in vacuo
4. 4
   其他the crude product is purified by HPLC (MeOH/H2O/NH3)

实验过程

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

来源