反应 #68747

反应方程式

2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

→

2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

溶剂

acetone

hydrochloric acid

water

hydrochloric acid

反应条件

后处理

1. 1
   萃取the crude product is extracted with ethyl acetate (3×15 ml)
2. 2
   洗涤washed with brine (10 ml)
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   过滤filtered
5. 5
   其他the filtrate is evaporated to dryness under reduced pressure

实验过程

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

来源