反应 #684975

反应方程式

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

收率 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

收率 84.4%

溶剂

dimethylformamide

反应条件

后处理

1. 1
   洗涤the reaction mixture was washed with saturated brine
2. 2
   浓缩concentrated under reduced pressure
3. 3
   其他The residue was purified by silica gel column chromatography

实验过程

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

来源