反应 #684974

反应方程式

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

收率 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

收率 84.1%

溶剂

methylene chloride

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   洗涤The ethyl acetate layer was washed with saturated brine
3. 3
   浓缩concentrated under reduced pressure
4. 4
   其他The residue was purified by silica gel column chromatography

实验过程

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

来源