反应 #684971

反应方程式

Trifluoroacetic acid

compound

2-(4-Butylbenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

ethyl acetate

→

title compound

收率 88.8%

2-(4-Butylbenzyl)-3-pyridinol

收率 88.8%

溶剂

methylene chloride

反应条件

后处理

1. 1
   洗涤the reaction mixture was washed with saturated brine
2. 2
   浓缩concentrated under reduced pressure
3. 3
   其他The residue was purified by silica gel column chromatography

实验过程

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

来源