反应 #684970

反应方程式

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

收率 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

收率 67.7%

溶剂

acetone

反应条件

后处理

1. 1
   温度while heating
2. 2
   温度under reflux for 4 hours
3. 3
   过滤The reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   其他to remove insoluble material
6. 6
   过滤by filtration
7. 7
   浓缩the filtrate was concentrated under reduced pressure
8. 8
   其他The residue was purified by silica gel column chromatography

实验过程

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

来源