反应 #684969

反应方程式

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

收率 80.1%

4-Bromo-1-isoquinolinol

收率 80.1%

溶剂

tetrahydrofuran

acetic acid

反应条件

后处理

1. 1
   其他the resulting reaction mixture
2. 2
   过滤was filtered
3. 3
   过滤through filter paper
4. 4
   洗涤The organic layer was washed with saturated brine
5. 5
   浓缩concentrated under reduced pressure
6. 6
   其他The residue was recrystallized from ethyl acetate and hexane

实验过程

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

来源