反应 #684965

反应方程式

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

收率 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

收率 94.6%

反应条件

后处理

1. 1
   温度under reflux for 19 hours
2. 2
   浓缩The mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   其他to precipitate crystals
5. 5
   过滤The obtained crystals were collected by filtration
6. 6
   洗涤washed with water
7. 7
   其他dried

实验过程

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

来源