反应 #684962

反应方程式

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

收率 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

收率 72.6%

溶剂

tetrahydrofuran

methanol

反应条件

后处理

1. 1
   其他The catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   其他precipitates
4. 4
   其他were removed by filtration
5. 5
   浓缩the obtained filtrate was concentrated

实验过程

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

来源