反应 #684959

反应方程式

water

potassium carbonate

t-butyl bromide

4-pentynoic acid

→

title compound

t-Butyl 4-pentynoate

溶剂

N,N-dimethylacetamide

反应条件

后处理

1. 1
   萃取the reaction mixture was extracted with ethyl acetate
2. 2
   洗涤washed with water
3. 3
   干燥dried over anhydrous magnesium chloride
4. 4
   过滤filtered through silica gel
5. 5
   浓缩The filtrate was concentrated under reduced pressure

实验过程

Benzyltriethylammonium chloride (5.92 g), potassium carbonate (93.4 g), and t-butyl bromide (143 ml) were added to a solution of 4-pentynoic acid (2550 mg) in N,N-dimethylacetamide (230 ml), and this reaction mixture was stirred at 55° C. for 24 hours. After water was added, the reaction mixture was extracted with ethyl acetate, washed with water, dried over anhydrous magnesium chloride, and then filtered through silica gel. The filtrate was concentrated under reduced pressure to give the title compound (2.10 g). This compound was used in the following reaction without further purification.

来源