反应 #684956

反应方程式

Dimethylamine

triethylamine

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

4-pentynoic acid

→

title compound

N,N-dimethyl-4-pentynamide

溶剂

methylene chloride

反应条件

后处理

1. 1
   洗涤The reaction mixture was washed successively with 1 N hydrochloric acid
2. 2
   干燥a saturated aqueous sodium hydrogencarbonate solution, water, and saturated brine, dried over anhydrous magnesium sulfate
3. 3
   浓缩concentrated under reduced pressure

实验过程

Dimethylamine (2 M solution in tetrahydrofuran, 8.53 ml), triethylamine (2.59 ml), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (3221 mg), were added to a solution of 4-pentynoic acid (552 mg) in methylene chloride (150 ml) and this reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was washed successively with 1 N hydrochloric acid, a saturated aqueous sodium hydrogencarbonate solution, water, and saturated brine, dried over anhydrous magnesium sulfate, then concentrated under reduced pressure to give the title compound (129 mg). The obtained compound was used in the following reaction without further purification.

来源