反应 #684953

反应方程式

ethynylbenzene

pyrrolidine

pyrrolidine

→

title compound

1-[2-(2-Phenyl-1-ethynyl)benzyl]isoquinoline

溶剂

ethyl acetate

反应条件

后处理

1. 1
   温度The mixture was cooled to room temperature
2. 2
   洗涤washed with a saturated aqueous ammonium chloride solution
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   浓缩concentrated under reduced pressure
5. 5
   其他The residue was purified by silica gel chromatography

实验过程

A solution of tetrakis(triphenylphosphine)palladium (58 mg, 0.05 mmol) and ethynylbenzene (204 mg, 2.0 mmol) in pyrrolidine (1.5 ml) was added to a solution of the compound of Example B25 (345 mg, 1.07 mmol) in pyrrolidine (1.5 ml) under nitrogen atmosphere, and the mixture was stirred at 80° C. for 3 hours. The mixture was cooled to room temperature, diluted with ethyl acetate, washed with a saturated aqueous ammonium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the title compound (280 mg).

来源