反应 #67989

反应方程式

methyl 3-oxo-3-(1,3-thiazol-2-yl)propionate

m-anisidine

→

N-(3-methoxyphenyl)-3-oxo-3-(1,3-thiazol-2-yl)propaneamide

溶剂

xylene

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   温度under reflux
3. 3
   温度by heating
4. 4
   其他The solvent was removed under reduced pressure, and water and ethyl acetate
5. 5
   workup.ADDITIONwere added
6. 6
   其他The organic layer was separated
7. 7
   萃取the aqueous layer was extracted with ethyl acetate
8. 8
   洗涤the resultant solution was washed with an aqueous saturated sodium chloride solution
9. 9
   干燥dried over anhydrous magnesium sulfate
10. 10
    其他the solvent was removed under reduced pressure

实验过程

To 30 mL of a xylene solution containing 2.3 g of methyl 3-oxo-3-(1,3-thiazol-2-yl)propionate, 1.4 mL of m-anisidine was added. The reaction mixture was stirred for 6 hours under reflux by heating. The solvent was removed under reduced pressure, and water and ethyl acetate were added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 3.3 g of a brown oily substance, N-(3-methoxyphenyl)-3-oxo-3-(1,3-thiazol-2-yl)propaneamide.

来源