反应 #67640

反应方程式

Compound 1035

N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide

2-chloro pyrazine

water

→

N-(5-(pyrazin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide

收率 9.7%

溶剂

NMP

反应条件

后处理

1. 1
   过滤the crude product collected by filtration
2. 2
   其他The crude solid was purified by silica gel chromatography (CH2Cl2 to EtOH)

实验过程

As shown in step 10-iv of Scheme 10, to a solution of 50 mg of Compound 1035 in 3 mL of NMP was added 100 mg of 2-chloro pyrazine. The reaction mixture was warmed to 250° C. for 10 minutes under microwave irradiation. The reaction was poured into water (10 mL) and the crude product collected by filtration. The crude solid was purified by silica gel chromatography (CH2Cl2 to EtOH) to provide N-(5-(pyrazin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide (Compound 1, 6.8 mg): ESMS (M+H) 276.16.

来源