反应 #67579

反应方程式

2-Chloropyrazine

methylhydrazine

→

N-Methyl-N-pyrazin-2-yl-hydrazine

收率 35.9%

反应条件

后处理

1. 1
   其他fitted with a water condenser
2. 2
   workup.WAITAfter a few minutes an exotherm was observed
3. 3
   其他After 16 h the excess methylhydrazine was removed under reduced pressure
4. 4
   萃取the resulting solution was extracted with ether (6×100 ml)
5. 5
   干燥The combined extracts were dried (K2CO3)
6. 6
   浓缩concentrated

实验过程

2-Chloropyrazine (1 g, 8.3 mmol) and methylhydrazine (1.31 mL, 25 mmol) were mixed together in a flask fitted with a water condenser. After a few minutes an exotherm was observed. After 16 h the excess methylhydrazine was removed under reduced pressure. The cooled residue was stirred with aqueous sodium hydroxide solution (20 ml of 20%), and the resulting solution was extracted with ether (6×100 ml). The combined extracts were dried (K2CO3) and concentrated to give a light orange solid 370 mg of N-Methyl-N-pyrazin-2-yl-hydrazine.

来源