反应 #674372

反应方程式

Ethyl 4-formyl-2-methylbenzoate

4-formyl-2-methylbenzoic acid

H2SO4

→

title compound

收率 80.0%

Ethyl 2-methyl-4-vinylbenzoate

收率 80.0%

溶剂

EtOH

反应条件

后处理

1. 1
   温度The reaction mixture was cooled to 25° C.
2. 2
   浓缩concentrated under reduced pressure
3. 3
   workup.ADDITIONThe residue was diluted with EtOAc
4. 4
   洗涤washed with water
5. 5
   洗涤The combined EtOAc extracts were washed with brine
6. 6
   干燥dried over Na2SO4
7. 7
   浓缩concentrated under reduced pressure

实验过程

Ethyl 4-formyl-2-methylbenzoate (AI16). To a stirred solution of 4-formyl-2-methylbenzoic acid (3 g, 18.2 mmol) in EtOH (30 mL) was added conc. H2SO4 (2 mL) and the reaction mixture was heated at 80° C. for 18 h. The reaction mixture was cooled to 25° C. and concentrated under reduced pressure. The residue was diluted with EtOAc and washed with water. The combined EtOAc extracts were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as a solid (2.8 g, 80%): 1H NMR (400 MHz, CDCl3) δ 10.05 (s, 1H), 8.04 (m, 1H), 7.75 (m, 2H), 4.43 (m, 2H), 2.65 (s, 3H), 1.42 (m, 3H).

来源