反应 #674364

ord-4219b9baea0b4cfdb035e4c0fe1893fd

反应方程式

NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
Cl.c1ncc2c(n1)CNC2
6,7-dihydro-5H-pyrrolo[3,4-d]pyrim idine hydrochloride
→
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3Cc4cncnc4C3)n2)c1
3-[(4-(5H-Pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

反应物

NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
Cl.c1ncc2c(n1)CNC2
6,7-dihydro-5H-pyrrolo[3,4-d]pyrim idine hydrochloride

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他B50 was prepared

实验过程

B50 was prepared following the general procedure reported for B10 using A1 and 6,7-dihydro-5H-pyrrolo[3,4-d]pyrim idine hydrochloride; yield: 205.4 mg (53%), colorless amorphous solid. MS (ES) C16H16N8O2S requires: 384. found: 385 (M+H)+.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09226929B2uspto-grants-2016_01