反应 #674359

反应方程式

A1

3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride

→

3-[(4-(6,7-Dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

反应条件

后处理

1. 1
   其他B45 was prepared
2. 2
   其他The title compound (B45) was purified by column chromatography (silica gel, DCM/MeOH gradient 100:0 to 85:15)

实验过程

B45 was prepared following the general procedure reported for B10 using A1 and 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride. The title compound (B45) was purified by column chromatography (silica gel, DCM/MeOH gradient 100:0 to 85:15); yield: 28.9 mg (7%), colorless amorphous solid. 1H NMR (400 MHz, d6-DMSO, 300K) δ 2.84-2.94 (m, 2H), 4.13 (t, J=5.8 Hz, 2H), 4.23 (s, 2H), 5.03 (s, 2H), 6.83 (s, 2H), 7.00 (d, J=7.1 Hz, 1H), 7.29 (t, J=7.7 Hz, 1H), 7.42-7.63 (bm, 1H), 7.82-7.93 (bm, 1H), 8.28 (s, 1H), 8.96 (s, 1H), 9.77 (s, 1H). MS (ES) C16H17N7O2S2 requires: 403. found: 404 (M+H)+.

来源