反应 #674347

ord-e65502a2b9a2488bb040db32d07e044c

反应方程式

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
C1CN[C@H](CN2CCCC2)C1
(S)-2-((pyrrolidin-1-yl)methyl)pyrrolidine
→
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCC[C@H]3CN3CCCC3)n2)c1
(S)-3-[(4-(2-((Pyrrolidin-1-yl)methyl)pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

反应物

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
C1CN[C@H](CN2CCCC2)C1
(S)-2-((pyrrolidin-1-yl)methyl)pyrrolidine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他B32 was prepared
  2. 2
    其他obtained as a white crystalline solid

实验过程

B32 was prepared following the procedure reported for B4 using A1 and (S)-2-((pyrrolidin-1-yl)methyl)pyrrolidine and obtained as a white crystalline solid; yield: 87 mg (23%). MS (ES) C19H27N7O2S requires: 417. found: 418 (M+H)+.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09226929B2uspto-grants-2016_01