反应 #674344

ord-3215974729bb40739efc53d8843c552f

反应方程式

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
c1ccc(NC[C@H]2CCCN2)cc1
(R)-2-(phenylamino-methyl)pyrrolidine
→
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCC[C@@H]3CNc3ccccc3)n2)c1
(R)-3-[(4-(2-(Phenylamino-methyl)pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

反应物

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
c1ccc(NC[C@H]2CCCN2)cc1
(R)-2-(phenylamino-methyl)pyrrolidine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他B29 was prepared
  2. 2
    其他It was obtained as a white crystalline solid

实验过程

B29 was prepared following the procedure reported for B4 using A1 and (R)-2-(phenylamino-methyl)pyrrolidine. It was obtained as a white crystalline solid; yield: 245 mg (62%). MS (ES) C21H25N7O2S requires: 439. found: 440 (M+H)+.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09226929B2uspto-grants-2016_01