反应 #674332

ord-56d15c77a9554388a656b341305bdd3f

反应方程式

NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
C[C@@H]1CCCN1
(R)-2-methylpyrrolidine
→
C[C@@H]1CCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
(R)-3-[(4-(2-Methylpyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

反应物

NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
C[C@@H]1CCCN1
(R)-2-methylpyrrolidine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他B15 was prepared

实验过程

B15 was prepared following the general procedure reported for B10 using A1 and (R)-2-methylpyrrolidine. Yield: 31.5 mg (9%), colorless amorphous solid. MS (ES) C15H20N6O2S requires: 348. found: 349 (M+H)+.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09226929B2uspto-grants-2016_01