反应 #674327

反应方程式

triazine

3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

morpholine

DIPEA

→

3-[(4-(Morpholin-4-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamide

溶剂

THF

iPrOH

反应条件

后处理

1. 1
   其他the solvent removed under reduced pressure
2. 2
   workup.ADDITIONThe residue was treated with MeOH
3. 3
   过滤the solid title compound (B10) collected by filtration
4. 4
   洗涤washed with MeOH
5. 5
   其他dried in vacuo

实验过程

To a solution of triazine A1 (300 mg, 1.0 mmol) in a mixture of THF (4 mL) and iPrOH (4 mL) were added morpholine (87 mg, 1.0 mmol) and DIPEA (200 μL, 1.15 mmol). The mixture was heated for 2 hours at 60° C. and the solvent removed under reduced pressure. The residue was treated with MeOH and the solid title compound (B10) collected by filtration, washed with MeOH, and dried in vacuo. Yield: 93.3 mg (27%), colorless amorphous solid. MS (ES) C14H18N6O3S requires: 350. found: 351 (M+H)+.

来源