反应 #674315

反应方程式

methylphenidate hydrochloride

Ammonium hydroxide

→

oil

收率 98.0%

d-Methylphenidate

收率 98.0%

溶剂

water

反应条件

后处理

1. 1
   其他formed
2. 2
   萃取The product was extracted with three 100 mL portions of ethyl acetate
3. 3
   干燥the combined organic layers were dried over sodium sulfate
4. 4
   过滤filtered
5. 5
   浓缩concentrated
6. 6
   其他at 40° C.

实验过程

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. Ammonium hydroxide (3.40 g; 96.8 mmol) was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduce pressure at 40° C. to provide 8.5 g of a clear, colorless viscous oil (98% yield). The free base was characterized by FTIR and found to be consistent with the anticipated structure

来源