反应 #674309

反应方程式

tert-butyl 7-(benzyloxy)-2-azaspiro[3.5]nonane-2-carboxylate

Hydrogen

→

tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate

收率 94.1%

溶剂

MeOH

反应条件

后处理

1. 1
   洗涤eluted with MeOH (50 mL)
2. 2
   浓缩The combined methanol solution was concentrated

实验过程

To a solution of tert-butyl 7-(benzyloxy)-2-azaspiro[3.5]nonane-2-carboxylate (290 mg, 0.96 mmol, 1.0 equiv) in MeOH (8 mL) was added Pd(OH)2 (43.5 mg, 15 wt %). The mixture was carefully vacuumed and refilled with Hydrogen. The mixture was then stirred at room temperature under hydrogen balloon for 2 hrs. The mixture was passed through a pad of celite and eluted with MeOH (50 mL). The combined methanol solution was concentrated to afford 218 mg (yield 94%) of tert-butyl 7-hydroxy-2-azaspiro[3.5]nonane-2-carboxylate as a pale yellow solid.

来源