反应 #674287

ord-9fb1ff1cb2d94f1da5086a474289cc48

反应方程式

[Ca+2].[Cl-].[Cl-]
calcium chloride
O=P([O-])([O-])O
hydrogen phosphate
[Na+].[OH-]
NaOH
O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2]
Calcium Phosphate

溶剂

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他CaP NPs
  2. 2
    其他were obtained by filtration of the suspension through a 0.22 μm
  3. 3
    过滤filter
  4. 4
    其他CaP NPs
  5. 5
    其他were stored at 4° C. before use
  6. 6
    其他CaP/ZOL-NPs complexes (CaPZ NPs) were prepared

实验过程

An aqueous solution of calcium chloride (18 mM) was added, dropwise and under magnetic stirring, to an aqueous solution on dibasic hydrogen phosphate (10.8 mM). The pH of both solutions was adjusted beforehand to 9.5 with NaOH. CaP NPs were obtained by filtration of the suspension through a 0.22 μm filter. CaP NPs were stored at 4° C. before use. CaP/ZOL-NPs complexes (CaPZ NPs) were prepared by mixing a CaP NPs dispersion with an aqueous solution of (50 mg/ml of ZOL in phosphate buffer at pH 9.5), at a volume ratio of 50:1.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09226897B2uspto-grants-2016_01