反应 #6710

反应方程式

N-Methyl-piperidine-2-carboxylic acid ethyl ester

NaOH

hydrochloric acid

→

N-methyl-piperidine-2-carboxylic acid

溶剂

methanol

water

反应条件

后处理

1. 1
   其他evaporated to dryness
2. 2
   其他evaporated four times with toluene

实验过程

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

来源