反应 #6702

反应方程式

water

4-Bromobenzaldehyde

p-toluenesulfonic acid monohydrate

ethylene glycol

→

2-(4-bromophenyl)-1,3-dioxolane

溶剂

ethyl acetate

benzene

反应条件

后处理

1. 1
   洗涤This solution was washed twice with aqueous bicarbonate
2. 2
   干燥dried over magnesium sulfate
3. 3
   浓缩concentrated under reduced pressure
4. 4
   其他A colorless oil was recovered

实验过程

4-Bromobenzaldehyde (3 g, 0.0162 mol) in benzene (60 mL) was treated with p-toluenesulfonic acid monohydrate (0.15 g, 0.79 mmol) and ethylene glycol (5 mL, 0.0896 mol). The reaction was refluxed under nitrogen with azeotropic removal of water. After 3 hours, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This solution was washed twice with aqueous bicarbonate, dried over magnesium sulfate and concentrated under reduced pressure. A colorless oil was recovered. Yield=2.83 g (92%). TLC (5% ethyl acetate in hexanes) showed clean product, Rf=0.17.

来源