反应 #669944

反应方程式

SnCl2.2H2O

NaNO2

acid

4-Amino-5,6,7,8-tetrahydro-1-naphthalenesulphonic acid

→

expected product

收率 77.7%

4-Hydrazino-5,6,7,8-tetrahydro-1-naphthalenesulphonic acid hydrochloride

收率 77.7%

溶剂

HCl

HCl

water

sodium hydroxide

反应条件

后处理

1. 1
   温度is maintained at 5° C
2. 2
   workup.WAITThe mixture is left
3. 3
   workup.STIRRINGstirring for one and a half hours at RT
4. 4
   过滤filtered
5. 5
   其他the residue is dried under vacuum

实验过程

1 g of NaNO2 is added to a solution of 3 g of the acid obtained in step A in 10 ml of water and 2 ml of 30% sodium hydroxide. This solution is poured over 1 hour into 10 ml of concentrated HCl cooled to 5° C. After stirring for 3 hours at 5° C., a solution of 7.5 g of SnCl2.2H2O in 15 ml of concentrated HCl is added slowly while the temperature is maintained at 5° C. The mixture is left stirring for one and a half hours at RT and filtered, and the residue is dried under vacuum to obtain 2.86 g of the expected product.

来源