反应 #6682

反应方程式

KOH

ethyl 4-benzyloxybenzoate

→

4-Benzyloxybenzoic acid

溶剂

MeOH

反应条件

后处理

1. 1
   温度After the resulting mixture was refluxed for 4 hrs
2. 2
   其他the excess methanol was removed
3. 3
   workup.ADDITIONThe residue was mixed with 30 ml water
4. 4
   萃取extracted with ether twice
5. 5
   萃取extracted with ethyl acetate
6. 6
   洗涤The ethyl acetate solution was washed with brine
7. 7
   其他dried
8. 8
   其他After evaporation of solvent
9. 9
   其他pure product was obtained in quantitative yield

实验过程

To the solution of 0.5 g KOH in 40 ml MeOH, was added 6.5 mmol of ethyl 4-benzyloxybenzoate. After the resulting mixture was refluxed for 4 hrs, the excess methanol was removed. The residue was mixed with 30 ml water and extracted with ether twice. The water solution was acidified with conc. HCl and extracted with ethyl acetate. The ethyl acetate solution was washed with brine and dried. After evaporation of solvent, pure product was obtained in quantitative yield.

来源