反应 #6673

反应方程式

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

溶剂

toluene

反应条件

后处理

1. 1
   温度was refluxed for 24 hours
2. 2
   温度After cooling
3. 3
   过滤the reaction mixture was filtered
4. 4
   其他the solvent was evaporated
5. 5
   其他The product was crystallized from methanol

实验过程

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

来源