反应 #66729

反应方程式

4-Oxo-adamantane-1-carboxylic acid methyl ester

→

( 11 )

收率 91.5%

4-Oxo-adamantane-1-carboxylic acid

收率 91.5%

溶剂

LiOH MeOH

MeOH LiOH

反应条件

后处理

1. 1
   workup.STIRRINGstirring
2. 2
   萃取extracted three times with ethyl acetate
3. 3
   干燥The organic layer was dried over sodium sulphate
4. 4
   其他evaporated to dryness

实验过程

1.64 g of 4-Oxo-adamantane-1-carboxylic acid methyl ester (10) were dissolved in 4 mL of 2M aq. LiOH/MeOH (1:1) and stirred overnight at room temperature. Additional 5 ml of the MeOH/LiOH mixture were added and stirring was continued until conversion was complete. The reaction mixture was acidified and extracted three times with ethyl acetate. The organic layer was dried over sodium sulphate and evaporated to dryness to give 1.4 g of (11) as a solid. Rt=0.87 min (Method 3). Detected mass: 195.2 (M+H+).

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