反应 #66672

反应方程式

2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene

ICl

NaHCO3

→

1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene

收率 91.8%

溶剂

HOAc

HOAc

H2O

反应条件

后处理

1. 1
   萃取The aqueous solution was extracted into EtOAc which
2. 2
   洗涤was washed with water, brine
3. 3
   干燥dried over Na2SO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated in vacuo

实验过程

To a solution of 2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene (10 g, 31.25 mmol) in HOAc (10 ml) was added a solution of ICl (9.6 g, 59.26 mmol) in HOAc (10 ml) and H2O (5 ml). The reaction mixture was stirred at room temperature for 16 hrs and basified by saturated NaHCO3 solution. The aqueous solution was extracted into EtOAc which was washed with water, brine, dried over Na2SO4, filtered and concentrated in vacuo to give 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (12.35 g, 89%).

来源