反应 #664438

反应方程式

(4-methyl-1,3-thiazol-5-yl)methanol

tribromophosphane

→

5-(bromomethyl)-4-methyl-1,3-thiazole hydrobromide

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他Dichloromethane was evaporated
2. 2
   其他the residue was then dried in vacuo

实验过程

To a solution of (4-methyl-1,3-thiazol-5-yl)methanol (2.5 g, 19.4 mmol) in anhydrous dichloromethane (100 mL) was added dropwise tribromophosphane (2.00 mL, 21.3 mmol). The mixture was stirred at room temperature for 3.5 hours. Dichloromethane was evaporated, and the residue was then dried in vacuo, affording 5-(bromomethyl)-4-methyl-1,3-thiazole hydrobromide. The product was used for the next step without further purification.

来源