反应 #66380

反应方程式

2,4-difluoro-phenylamine

N,N-dimethylformamide

benzyl bromide

→

dibenzyl-(2,4-difluoro-phenyl)-amine

收率 90.0%

溶剂

water

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   洗涤The organic layer was washed with brine
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   过滤filtered
5. 5
   浓缩The filtrate was concentrated under reduced pressure
6. 6
   其他purified by silica gel column chromatography
7. 7
   洗涤eluting with hexane

实验过程

To 2,4-difluoro-phenylamine (a, 2.0 g, 15.5 mmol) in N,N-dimethylformamide (20 mL) potassium carbonate (6.0 g, 45 mmol) and benzyl bromide (5.49 mL, 35 mmol) were added. The reaction was stirred at room temperature overnight. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography eluting with hexane to give dibenzyl-(2,4-difluoro-phenyl)-amine as colourless oil (4.34 g, 90%).

来源