反应 #66107

反应方程式

2-Cyclopentyl-5,6,7,8-tetrahydro-indolizine

toluene

Oxalyl chloride

→

(2-cyclopentyl-5,6,7,8-tetrahydro-indolizin-3-yl)-oxo-acetyl chloride

收率 88.0%

溶剂

THF

反应条件

后处理

1. 1
   workup.WAITat room temperature for 1 hour
2. 2
   浓缩Concentration in vacuo

实验过程

2-Cyclopentyl-5,6,7,8-tetrahydro-indolizine (0.24 g, 1.27 mmol) was dissolved in THF (1 mL) and toluene (1.5 mL) and cooled to 0° C. Oxalyl chloride (0.14 mL, 1.52 mmol) was added dropwise and the mixture was stirred at 0° C. for 30 min, then at room temperature for 1 hour. Concentration in vacuo afforded (2-cyclopentyl-5,6,7,8-tetrahydro-indolizin-3-yl)-oxo-acetyl chloride (0.31 g, 88%) as a semi-solid.

来源