反应 #66106

反应方程式

Oxalyl chloride

2-phenyl-5,6,7,8-tetrahydro-indolizine

→

oxo-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetyl chloride

收率 91.2%

溶剂

toluene

THF

反应条件

后处理

1. 1
   浓缩then concentrated under vacuum
2. 2
   其他The residue was triturated with petrol (5×300 mL)

实验过程

Oxalyl chloride (17.2 mL, 0.19 mol) was added to an ice-cold solution of 2-phenyl-5,6,7,8-tetrahydro-indolizine (32 g, 0.16 mol) in a mixture of toluene (20 mL) and THF (30 mL). The reaction mixture was allowed to warm to room temperature and stirred for 30 min. then concentrated under vacuum. The residue was triturated with petrol (5×300 mL) to afford oxo-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetyl chloride (42 g, 89%) as a dark yellow solid.

来源