反应 #66103

反应方程式

1-(2-Cyclopentyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt

→

2-cyclopentyl-indolizine

收率 41.0%

溶剂

sodium bicarbonate

water

反应条件

后处理

1. 1
   温度to cool
2. 2
   萃取extracted with ethyl acetate (×2)
3. 3
   洗涤The combined organic phases were washed with water and brine
4. 4
   干燥dried over sodium sulfate
5. 5
   浓缩concentrated
6. 6
   其他to give a residue which
7. 7
   其他was purified by column chromatography

实验过程

1-(2-Cyclopentyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt (3.4 g, 12.0 mmol) was heated at reflux in saturated sodium bicarbonate solution for 3 hrs. The mixture was allowed to cool, diluted with water and extracted with ethyl acetate (×2). The combined organic phases were washed with water and brine, dried over sodium sulfate and concentrated to give a residue which was purified by column chromatography using 100-200 mesh silica-gel and 1% ethyl acetate/petroleum-ether as eluent to afford 2-cyclopentyl-indolizine (0.91 g, 41%) as a solid.

来源