反应 #66102

反应方程式

2-bromo-1-(tetrahydro-pyran-4-yl)-ethanone

2-picoline

→

2-methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide

收率 86.4%

溶剂

methanol

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度to reflux
3. 3
   温度maintained overnight
4. 4
   其他The solvent was removed in vacuo
5. 5
   其他to give a residue which
6. 6
   洗涤was washed with 20% ethyl acetate in hexane

实验过程

A mixture of 2-bromo-1-(tetrahydro-pyran-4-yl)-ethanone (0.6 g, 2.89 mmol) and 2-picoline (0.4 mL, 4.3 mmol) in methanol (10 mL) was heated to reflux and maintained overnight. The solvent was removed in vacuo to give a residue which was washed with 20% ethyl acetate in hexane to afford 2-methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide (0.75 g, 86%) as a semi-solid.

来源