反应 #66100

反应方程式

2-Bromo-1-(1-bromo-cyclopentyl)-ethanone

α-picoline

→

1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt

收率 117.6%

溶剂

acetone

反应条件

后处理

1. 1
   温度at reflux overnight
2. 2
   温度to cool
3. 3
   浓缩then concentrated in vacuo
4. 4
   洗涤The crude mass was washed with 30% ethyl acetate/petroleum ether and diethyl ether

实验过程

2-Bromo-1-(1-bromo-cyclopentyl)-ethanone (3.7 g, 13.7 mmol) and α-picoline (1.02 g, 11.0 mmol) in acetone were heated at reflux overnight. The reaction mixture was allowed to cool then concentrated in vacuo. The crude mass was washed with 30% ethyl acetate/petroleum ether and diethyl ether. 1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt (3.65 g, 94%) was obtained as a semi-solid material and taken for next step without purification.

来源