反应 #66096

反应方程式

1-methyl-piperidine-4-carboxylic acid ethyl ester

hydrochloric acid

→

1-methyl-piperidine-4-carboxylic acid hydrochloride

收率 48.0%

反应条件

后处理

1. 1
   温度maintained for 6 h
2. 2
   浓缩The mixture was then concentrated to dryness in vacuo
3. 3
   其他to give a solid, which
4. 4
   洗涤was washed with acetonitrile-diethyl ether (1:1)
5. 5
   其他dried in vacuo

实验过程

A solution of 1-methyl-piperidine-4-carboxylic acid ethyl ester (2.0 g, 11.7 mmol) in conc. hydrochloric acid (20 mL) was heated to 100° C. and maintained for 6 h. The mixture was then concentrated to dryness in vacuo to give a solid, which was washed with acetonitrile-diethyl ether (1:1) and dried in vacuo to afford 1-methyl-piperidine-4-carboxylic acid hydrochloride (1.0 g, 48%) as an off-white solid.

来源