反应 #66094

反应方程式

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

dimethylaminopyridine

acetonitrile

diazabicyclononane

water

→

crystalline compound

6-Chloro-3-(1,4-diazabicyclo[3.2.2]non-4-ylcarbonyl)-1H-pyrrolo[2,3-b]pyridine

反应条件

后处理

1. 1
   萃取extracted with dichloromethane
2. 2
   其他the organic phase is evaporated

实验过程

375 mg (2 mmol) of the derivative from the preceding step, 760 mg (4 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 50 mg of dimethylaminopyridine, 5 ml of acetonitrile and 500 mg (4 mmol) of diazabicyclononane are placed in a microwave tube (Personal Chemistry), and the tube is stoppered and heated at 100° C. for 10 minutes. The mixture is immersed in 50 ml of water and extracted with dichloromethane, and the organic phase is evaporated. By trituration in isopropyl ether, 310 mg of a crystalline compound are obtained.

来源