反应 #66035

反应方程式

water

carbazole

4-fluoroacetophenone

K2CO3

→

product

1-(4-Carbazol-9-yl-phenyl)ethanone

溶剂

DMSO

反应条件

后处理

1. 1
   其他to afford a precipitate
2. 2
   其他which is isolated by filtration
3. 3
   洗涤washed with water
4. 4
   其他The crude product thus obtained
5. 5
   其他is further purified by recrystallization from TBME (tert-butyl methyl ether)

实验过程

To carbazole (5.02 g) in DMSO (50 mL) is added 4-fluoroacetophenone (3.45 g) and K2CO3 (10.4 g), and the mixture is stirred at 135° C. overnight. The mixture is poured into water to afford a precipitate, which is isolated by filtration and washed with water. The crude product thus obtained is further purified by recrystallization from TBME (tert-butyl methyl ether), giving the product as a light brown solid. The structure is confirmed by the 1H-NMR spectrum (CDCl3). δ [ppm]: 2.71 (s, 3H), 7.32 (ddd, 2H), 7.41-7.50 (m, 4H), 7.72 (d, 2H), 8.15 (d, 2H), 8.21 (d, 2H).

来源