反应 #657349

反应方程式

5-methoxyanthranilic acid

acetic anhydride

→

title compound

收率 77.0%

2-methyl-6-(methyloxy)-4H-3,1-benzoxazin-4-one

收率 77.0%

反应条件

后处理

1. 1
   温度before being cooled
2. 2
   浓缩concentrated under reduced pressure
3. 3
   浓缩The crude residue was then concentrated twice in the presence of toluene
4. 4
   过滤before being filtered
5. 5
   洗涤washed with ether

实验过程

A solution of 5-methoxyanthranilic acid (7.8 g, 46.5 mmol) was refluxed in acetic anhydride (60 mL) for 2 h15 before being cooled and concentrated under reduced pressure. The crude residue was then concentrated twice in the presence of toluene before being filtered and washed with ether to yield to the title compound (6.8 g, 77% yield) as a beige solid; LC/MS: m/z 192 [M+H]+, Rt 1.69 min.

来源