反应 #657298

反应方程式

Potassium carbonate

Monochloroacetic acid

potassium carbonate

CO2

hydrazine hydrate

→

2,2′-(hydrazine-1,1-diyl)diacetic acid

溶剂

water

反应条件

后处理

1. 1
   其他rose to 70° C
2. 2
   温度The solution was then heated until the gas evolution
3. 3
   其他At the end of the reaction
4. 4
   其他the 2,2′-(hydrazine-1,1-diyl)diacetic acid was precipitated
5. 5
   其他The product (mp 171° C.) was crystallized from water

实验过程

Monochloroacetic acid (2 eq.) in water was neutralized with potassium carbonate (1 eq.) followed by the addition of hydrazine hydrate (1 eq.). Potassium carbonate (1 eq.) was added to the solution gradually, whereupon, with a steady evolution of CO2, the temperature rose to 70° C. The solution was then heated until the gas evolution stopped. At the end of the reaction, the 2,2′-(hydrazine-1,1-diyl)diacetic acid was precipitated by making the solution acidic with concentrated HCl. The product (mp 171° C.) was crystallized from water, and was confirmed by NMR spectroscopy and elemental analysis.

来源