反应 #656991

反应方程式

4-bromo-2-fluorobenzylamine

triethylamine

4-bromo-2-nitrobenzoyl chloride

→

4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide

收率 81.9%

溶剂

chloroform

chloroform

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred at the same temperature for 1 hour
2. 2
   洗涤The reaction mixture was washed in turn with diluted aqueous hydrochloric acid and water
3. 3
   其他dried
4. 4
   其他Evaporation of the solvent
5. 5
   其他followed by recrystallization from diethyl ether

实验过程

To a solution of 4-bromo-2-fluorobenzylamine (2.3 g) and triethylamine (1.55 ml) in chloroform (40 ml) was added dropwise a solution of 4-bromo-2-nitrobenzoyl chloride (2.69 g) in chloroform (10 ml) at 0° C. with stirring and the mixture was stirred at the same temperature for 1 hour. The reaction mixture was washed in turn with diluted aqueous hydrochloric acid and water, and then dried. Evaporation of the solvent followed by recrystallization from diethyl ether gave 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.60 g).

来源