反应 #656990

反应方程式

7-chloro-2H-3,1-benzoxazine-2,4(1H)dione

4-bromo-2-fluorobenzylamine

→

2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide

收率 79.9%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   温度was refluxed for 15 minutes
2. 2
   温度After cooling
3. 3
   其他tetrahydrofuran was evaporated
4. 4
   其他to give a residue
5. 5
   其他Recrystallization from isopropyl ether

实验过程

A mixture of 7-chloro-2H-3,1-benzoxazine-2,4(1H)dione (18.4 g) and 4-bromo-2-fluorobenzylamine (26 g) in tetrahydrofuran (200 ml) was refluxed for 15 minutes. After cooling, tetrahydrofuran was evaporated to give a residue. Recrystallization from isopropyl ether gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide (26.6 g).

来源