反应 #656787

反应方程式

dichloromethyl 2-(p-chlorophenoxy)-ethyl ether

triethyl phosphite

ethyl chloride

→

Tetraethyl [2-(p-chlorophenoxy)-ethoxymethylene]-bisphosphonate

溶剂

ether

反应条件

后处理

1. 1
   温度the mixture was cooled
2. 2
   洗涤washed with aqueous sodium bicarbonate
3. 3
   其他dried
4. 4
   其他evaporated
5. 5
   其他Unreacted triethyl phosphite was removed in vacuo
6. 6
   其他the crude product was used in the next step without further purification

实验过程

Anhydrous zinc chloride (10 g) was added at 150° C. to a mixture of dichloromethyl 2-(p-chlorophenoxy)-ethyl ether (5.1 g) and triethyl phosphite (6.9 ml). When the evolution of ethyl chloride ceased, the mixture was cooled, taken up in ether (250 ml), washed with aqueous sodium bicarbonate, dried and evaporated. Unreacted triethyl phosphite was removed in vacuo, and the crude product was used in the next step without further purification.

来源