反应 #65159

反应方程式

Sodium methylate

1-methylpiperidine-4-thiol

chloroacetone

→

1-methyl-4-[(2-oxopropyl)thio]piperidine

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   过滤the precipitate is filtered off
2. 2
   浓缩the filtrate is concentrated
3. 3
   其他chromatographed on silica gel (eluent

实验过程

Sodium methylate (5.9 g) is added in portions to a solution of 1-methylpiperidine-4-thiol (14 g) in anhydrous tetrahydrofuran (100 ml) at room temperature. After 2 hours at this temperature, chloroacetone (8.8 ml) is added dropwise. After 24 hours, the precipitate is filtered off and the filtrate is concentrated and chromatographed on silica gel (eluent: ethyl acetate, then ethanol) to give 1-methyl-4-[(2-oxopropyl)thio]piperidine (11.5 g) in the form of an oil.

来源