反应 #64957

反应方程式

trans-1-benzyl-3-benzylmethylamino-4-methoxy-pyrrolidine

hydrochloric acid

→

trans-4-Methoxy-3-methylamino-pyrrolidine dihydrochloride

溶剂

methanol

反应条件

后处理

1. 1
   过滤The catalyst is filtered off with suction
2. 2
   浓缩the filtrate is concentrated
3. 3
   其他the residue is recrystallized from isopropanol/methanol

实验过程

9.3 g (29 mmol) of trans-1-benzyl-3-benzylmethylamino-4-methoxy-pyrrolidine are dissolved in 100 ml of methanol, 4.8 ml of concentrated hydrochloric acid are added and the mixture is hydrogenated on 4 g of 10% strength Pd-on-active charcoal at 90° C. under 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is recrystallized from isopropanol/methanol.

来源